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doi: 10.1007/s00228-006-0209-9.CrossRefGoogle ScholarPubMed Hiemke, C, Bergemann, N, Clement, HW, Conca, A, Deckert, J, Domschke, K, Eckermann, G, Egberts, K, Gerlach, M, Greiner, C, Grnder, G, Haen, E, Havemann-Reinecke, U, Hefner, G, Helmer, R, Janssen, G, Jaquenoud, E, Laux, G, Messer, T, Mssner, R, Mller, MJ, Paulzen, M, Pfuhlmann, B, Riederer, P, Saria, A, Schoppek, B, Schoretsanitis, G, Schwarz, M, Gracia, MS, Stegmann, B, Steimer, W, Stingl, JC, Uhr, M, Ulrich, S, Unterecker, S, Waschgler, R, Zernig, G, Zurek, G and Baumann, P (2018) Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: update 2017

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Irritability, often anxiety's aftermath, seems to peak at about 48 hours while restlessness peaks at 72 hours

She also noted that if smokers supplement the VLN cigarettes with their usual cigarettes, that might not lead to as much of a reduction in smoking